Although various studies have examined the short-term effects of a ketogenic diet in reducing weight in obese patients, its long-term effects on various physical and biochemical parameters are not known. The body weight, body mass index, total cholesterol, low density lipoprotein LDL cholesterol, high density lipoprotein HDL cholesterol, triglycerides, fasting blood sugar, urea and creatinine levels were determined before and after the administration of the ketogenic diet. Changes in these parameters were monitored after eight, 16 and 24 weeks of treatment. The level of total cholesterol decreased from week 1 to week HDL cholesterol levels significantly increased, whereas LDL cholesterol levels significantly decreased after treatment. The level of triglycerides decreased significantly following 24 weeks of treatment. The level of blood glucose significantly decreased. The changes in the level of urea and creatinine were not statistically significant. The present study shows the beneficial effects of a long-term ketogenic diet. It significantly reduced the body weight and body mass index of the patients.
However, rates of obesity and diabetes rose markedly throughout this period, with potentially catastrophic implications for public health and the economy. Recently, ketogenic diets have received substantial attention from the general public and nutrition research community. However, they have a long history in clinical medicine and human evolution. Ketogenic diets appear to be more effective than low-fat diets for treatment of obesity and diabetes. Based on available evidence, a well-formulated ketogenic diet does not appear to have major safety concerns for the general public and can be considered a first-line approach for obesity and diabetes. High-quality clinical trials of ketogenic diets will be needed to assess important questions about their long-term effects and full potential in clinical medicine. A century ago, the ketogenic diet was a standard of care in diabetes, used to prolong the life of children with type 1 diabetes and to control the symptoms of type 2 diabetes in adults 1. Discovery of insulin in the s enabled people with diabetes to control hyperglycemia on high-carbohydrate diets. However, the human toll and economic burden from diabetes complications continue to mount, despite increasingly sophisticated insulin analogs and drugs for associated conditions such as dyslipidemia, hypertension, and coagulopathy. Contrary to expectation, adoption of a higher-carbohydrate lower-fat diet by the US public in the second half of the 20th century could have contributed to the increasing prevalence of obesity 2, a major risk factor for type 2 diabetes.
J Diabetes Metab. Diet this article Vargas-Molina, Articles. Urbain P, Bertz Gesearch. A subscription may be required. References 1. Results showed that men increased their utilization of fats to research greater extent than women articles submaximal intensity exercise, suggesting some adaptations from a KD keto sex-specific. These changes keto associated with enhanced research Oxidative and non-oxidative glucose metabolism in non-obese type diet non-insulin dependent diabetic reseagch. Recent epidemiological studies 17, 58 — 60 could not explain a specific causal relationship between dietary fat and cancer.