Uremic retention solutes URS are associated with cardiovascular complications and poor survival in chronic kidney disease. The better understanding of the origin of a certain number of these toxins enabled the development of new strategies to reduce their production. URS can be classified according to their origins i. The discovery of the fundamental role that the intestinal microbiota plays in the production of many URS has reinstated nutrition at the heart of therapeutics to prevent the accumulation of URS and their deleterious effects. The intestinal microbiota is personalized and is strongly influenced by dietary habits, such as the quantity and the quality of dietary protein and fibers. Herein, this review out lines the role of intestinal microbiota on URS production and the recent discoveries on the effect of diet composition on the microbial balance in the host with a focus on the effect on URS production. Patients with chronic kidney disease CKD exhibit a high risk of cardiovascular CV diseases due to accelerated atherosclerosis and metabolic complications like dyslipidemia and perturbation of glucose homeostasis.
The quest for a better understanding of chronic kidney disease complications: an update on uremic toxins. Tilman B. Ziad A. Massy 4. Over the last decades, a large number of such compounds have been identified and their effects on organs and tissues, especially the cardiovascular system, has been demonstrated. The recognition that multiple toxins contribute to the uremia supports the need for new therapeutic targets, with a potentially positive impact on CKD progression and survival. In the last two decades, renewed interest has emerged about the uremic syndrome and its negative impact on chronic kidney disease CKD patient outcomes. The syndrome is primarily caused by the progressive decline in kidney function that leads to an accumulation of organic waste products. Under normal conditions, they are excreted by the kidneys.
The Journal publishes articles on basic or clinical research relating to nephrology, arterial hypertension, dialysis and kidney transplants. It is governed by the peer review system and all original papers are subject to internal assessment and external reviews. The journal accepts submissions of articles in English and in Spanish languages. The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two receding years. CiteScore measures average citations received per document published. SRJ is a prestige metric based on the idea that not all citations are the same. SNIP measures contextual citation impact by wighting citations based on the total number of citations in a subject field. Patients with chronic kidney disease present with an accumulation of uremic toxins, which have been identified as pathogenic agents associated with cardiovascular mortality, which is very high is this patient group. A phenomenon common to the progressive renal dysfunction and associated vascular damage, is the abnormal accumulation of extracellular matrix ECM proteins in the renal or vascular structures.. To determine the contribution of uremia or the uremic toxins to the production of cytokinins and ECM in aortas of uremic animals or human aortic smooth muscle cells HASMCs..